Abstract
Summary
1. The plasma clearance of I131-tagged, autologous hemoglobin was studied in the rat. 2. This radioactive hemoglobin was cleared at an exponential rate, having a half-life of 25 minutes. 3. Within the range of 3 to 10.2 mg hemoglobin per 100 g body weight, clearance rate was independent of dose administered. 4. No renal elimination of hemoglobin could be demonstrated. 5. Rapid release of I131 from the hemoglobin was noted. This considerably increased the plasma radioactivity value over the actual hemoglobin level after only 30 minutes.
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