Abstract
Summary
Saline suspensions of a variety of connective tissues and of collagen clump platelets in citrated platelet-rich plasma even in dilutions of 1:100. The effect is unrelated to blood clotting. The active material in human subcutaneous tissue is sedimented at 25,000 g in one hour, stable at 56°C, but not at 70°C, and destroyed by collagenase, form-amide and 25% alcohol but not by proteolytic enzymes. An inhibitor is present in liver. Similarities and differences between the effects of purified collagen, tissue suspensions and thrombin on platelets are described and the probable role of the connective tissue factor in hemostasis is discussed.
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