Abstract
Summary
The effects of L- and D-triiodothyronine (LT3 and DT3) administration and of propylthiouracil treatment on excretion of bile acids in male and female bile fistula rats have been studied. It has been shown that DT3 administered in doses with minimal calorigenic effects gives the same bile acid picture as is obtained in clearly hyperthyroid rats with the normal taurochenodeoxycholic/taurocholic acid ratio (TCD:TC) of about 1:3 shifted to 3:1. In the propylthiouracil-treated rats total daily production of bile acids after the bile acid pool had been excreted was only about one-fifth that found for normal and thyroid hormone-treated rats and the TCD:TC ratio was 1:9. No significant differences between male and female rats regarding bile acid excretion could be seen.
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