Abstract
Summary
Three all-dystrophic litters of mice from dydy matings were produced by artificial insemination of juvenile or young adult dystrophic females with sperm collected from dystrophic males, following induced ovulation in the female. Fertility and litter size of inbred and hybrid dystrophic {dydy) mice are compared to inbred and hybrid normal (Dy-) mice. It was found that hybrid dystrophic mice were far superior to inbred dystrophic mice and provided a practical means to obtain all-dystrophic litters. The insemination procedure makes it possible to obtain known dystrophic tissue at prenatal and early postnatal stages for histological and biochemical analyses.
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