Abstract
Summary
The effect of chronic selenosis on methionine and cystine content in liver of experimental animals was studied. The decrease in methionine in chronic selenosis was not associated with restricted food intake and subsequent starvation. In in vitro experiments, using rat liver homogenate, sodium selenate and selenite inhibited transmethylation reactions of homocystine and homocysteine by betaine and choline. Selenite was a more active biological inhibitor than selenate. The significance of the results was discussed with reference to the detoxification mechanism in selenium poisoning in animals.
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