Liver Pyridine Nucleotide Synthesis in the Vitamin B 6 -Deficient Rat. ∗

Abstract

Summary

Vit. B₆-deficient and pair-fed or ad lib.-fed control rats were injected with nicotinic acid or nicotinamide to determine the effect of Vit. B₆ deficiency on the ability of the rat to synthesize liver pyridine nucleotides. At 10 hours after injection of either compound, liver pyridine nucleotide concentration was significantly lower in the Vit. B₆-deficient rats than in the control rats. Liver pyridine nucleotide values were also significantly lower in the deficient rats at 1 and 4 hours after injection of nicotinic acid but not after injection of nicotinamide.