Abstract
Summary
Attenuation of Columbia SK virus by in vitro cultivation in 30 serial passages in Sarcoma 180 ascites cells is described, during which the virus lost neurotropic virulence and the HA property. Nonspecific HA inhibitor in the culture medium has no connection with the changed virus nature. The attenuated virus could be used as a live vaccine for prophylaxis of Columbia SK mouse infection.
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