In vitro Degradation of I 131 Labeled Angiotensin II by Normotensive and Hypertensive Human Serum. ∗

Abstract

Summary

Refrigeration of angiotensin II-I¹³¹ in vitro with human sera from normotensive, untreated primary benign hypertensive and secondary renal hypertensive subjects demonstrated that greater quantities of angiotensin II-I¹³¹ were degraded by the untreated primary benign hypertensive patients than by the normotensive or secondary renal hypertensive patients. Evidence for presence of a serum factor (or factors) enhancing angiotensin II-I¹³¹ degradation and for a heat labile inhibitor has been advanced. The greater in vitro degradation of angiotensin II-I¹³¹ by untreated primary benign hypertensive patients than by normotensive subjects contrasts with the in vivo turnover rates.