Abstract
Summary
Previous reports have suggested that the gastrointestinal tract plays a major role in development of irreversible endotoxin shock in the dog. However, results presented here do not support this view but show a statistically significant stepwise decrease in survival time as an increasing amount of visceral tissue is removed from the dog. These data indicate that the gut of the dog is not the “shock organ” but rather serves a protective role in endotoxin shock. A possible mechanism for development of the irreversible phase of endotoxin shock in the cat, rabbit, dog and monkey is suggested.
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