Abstract
Summary
Blood from femoral artery and vein and from portal vein of dogs was sampled before and 10, 20 and 30 minutes after injection of histamine. Oxygen content and pH of the blood was determined. Marked decrease of both O2 and pH of blood was found in all histamine treated animals as compared with untreated controls. The pattern of this reaction corresponds to one observed in stagnant anoxia and acidosis. Stagnant anoxia of splanchnic area which occurs after histamine is considered an important etiological factor responsible for the posthistaminic gastric lesions.
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