Abstract
Summary
Addition of 100-500 μg/ml of adenine under a variety of experimental conditions to Krebs 2 and Ehrlich ascites tumor cell suspension in a simplified medium was found to delay growth of encephalomyocarditis virus. The approximately 2-log lower yield in both supernatant and cell-associated virus observable at 24 hours was less apparent after this time. The replication of EMC virus in L cells as well as influenza, PR8, in CAM roller tubes, and deembryonated eggs was unaffected by adenine under the experimental conditions tested. Other related compounds were essentially without effect at nontoxic levels.
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