Abstract
Summary
Dogs inoculated with adenovirus type 4 developed complement-fixing and neutralizing antibodies following an asymptomatic course of infection. When such dogs were later inoculated with ICH virus, a secondary-type complement-fixing antibody response occurred to both viral antigens, and antibodies persisted for at least 340 days. Accelerated production of neutralizing antibody for ICH virus also occurred in these dogs. The duration of ICH viremia correlated with the development of neutralizing antibody. This secondary response to ICH virus created by heterotypic adenovirus may partially account for varied clinical manifestations observed in dogs with infectious canine hepatitis.
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