Stop Flow Analysis of Renal Tubular Site of Reabsorption of Radioiodide in Dogs. ∗

Abstract

Summary

The renal tubular site of reabsorption of iodide has been determined in the dog using the stop flow technic. The pattern for I¹³¹ was found to be qualitatively similar to that for chloride or sodium. However, I¹³¹ was reabsorbed to a lesser extent than chloride or sodium in both distal and proximal segments. Administration of large doses of stable iodide, perchlorate or thiosulfate did not greatly affect the stop flow ratios of I¹³¹. These experiments are interpreted as indicating passive reabsorption of iodide in both proximal and distal portions of the renal tubules of the dog.