Abstract
Summary
The technic of subcutaneous implantation of sutures infected with Staphylococcus aureus was used to assay protection of mice by pooled human gamma globulin. The mice which received 1 ml each of gamma globulin in divided doses showed 30 to 35% fewer purulent skin lesions than controls. The infected sutures, however, were not freed of viable staphylococci. This model system is regarded as being sufficiently satisfactory to warrant its continued use in experiments toward elucidation of critical factors in pathogenesis and protection.
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