Abstract
Summary
In adult female CF no. 1 mice, kidney enlargement after unilateral nephrectomy is a consequence mainly of hypertrophy. New cell formation as evidenced by an increase in total DNA content of the kidney may be a contributing factor in young animals but this becomes negligible with increasing age. The compensatory response occurring after uninephrectomy in the adult mouse is quite radioresistant, whether irradiation occurs immediately or 5 days post-operatively. This contrasts with the well-known radiosensitivity of cell renewal systems.
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