Abstract
Summary
A globulin concentrate from antiserum to bovine pituitary thyrotropin completly neutralized the effect on the thyroid of “long-acting thyroid stimulator” in the serum of patients with Graves' disease. Both early and late responses in the McKenzie assay were abolished. A globulin concentrate from normal rabbit serum had no neutralizing effect. About 10 times as much antibody was required to neutralize LATS as the approximately equivalent potency of human pituitary thyrotropin.
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