Abstract
Summary
Intrinsic factor or a mixture of IF and Co60B12 was injected intravenously to rabbits and rats in which a biliary fistula had been prepared, and excretion of B12 binding power or Co60 in bile was measured. It was found that significant amounts of B12 binding power or Co60 appeared in the bile within one hour and that such excretion began almost immediately following intravenous administration. A possible mechanism of hepatic uptake and subsequent excretion into bile of intravenously administred IF or its complex has been discussed.
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