Excretion into Bile of Intrinsic Factor and Its Vit. B 12 Complex Following Intravenous Injection

Abstract

Summary

Intrinsic factor or a mixture of IF and Co⁶⁰B₁₂ was injected intravenously to rabbits and rats in which a biliary fistula had been prepared, and excretion of B₁₂ binding power or Co⁶⁰ in bile was measured. It was found that significant amounts of B₁₂ binding power or Co⁶⁰ appeared in the bile within one hour and that such excretion began almost immediately following intravenous administration. A possible mechanism of hepatic uptake and subsequent excretion into bile of intravenously administred IF or its complex has been discussed.