Abstract
Summary
The aminonucleoside of puromycin (P-A), which produces the nephrotic syndrome in rats, was administered simultaneously with various nucleic acid intermediates. L-glutamine, D-glucosamine, and uridine intensified the nephrotoxicity, whereas guanine, adenylic acid, 4-amino-5-imidazole carboxamide, D-ribose, orotic acid, 2,6-diaminopurine, inosine, and thymine appeared to ameliorate the condition. Rats primed with L-triiodothyronine (T-3) developed proteinuria earlier than rats treated with P-A alone.
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