Abstract
Summary and Conclusions
Profound hypo-and hypernatremia were produced in rats of varying age. Resulting changes in bone Na content were much more pronounced in the younger animals, and decreased progressively as the animals became older. Calculated Na “space” of bone averaged 91% of bone water content for the 3 age groups studied. Observed changes in bone Na content could be ascribed entirely to that portion within the “fluid phase” of bone. There was no evidence of a change in “crystal phase” Na. Observed changes in adult rats were so slight that rather large changes in serum Na would be necessary for their detection.
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