Abstract
Summary
1. Nialamide increased the maximal electroshock seizure threshold in mice and rats. This effect was independent of the elevation of brain 5-HT and NE elicited by nialamide. 2. Diphenylhydantoin in doses from 6 to 55 mg/kg, which was almost 9 times the anticonvulsive dose, did not significantly alter the content of 5-HT or NE in the brain of mice. 3. Nialamide potentiated and reserpine decreased the anticonvulsant effect of diphenylhydantoin. No correlation could be found between these effects and brain amine levels.
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