Abstract
Conclusion
1. Intravenous administration of 9 α-fluorohydrocortisone and 2-methyl-9α-fluorohydrocortisone in doses sufficient to produce profound electrolyte effects in 6 salt-depleted and 6 salt-loaded subjects produced no significant change in glomerular filtration rate, with the exception of one salt-depleted subject, in whom there was an increase in both glomerular filtration rate and effective renal plasma flow following 2MeFF. 2. 2MeFF had a more profound sodium-retaining effect than did FF. Even in salt-depleted subjects, the sodium-retaining effects of both compounds were demonstrable. 3. FF had a more profound potassium-losing effect than did 2 MeFF. Kaliuresis was greater in the salt-loaded than in the salt-depleted subjects. 4. Plasma concentrations of sodium, potassium, and chloride did not change significantly during the 4 hour study after intravenous administration of the steroids.
Get full access to this article
View all access options for this article.