Decreased or Absent ACTH-Like Activity of Blocked Synthetic Tricosapeptide. ∗

Abstract

Summary

Substitution of acetyl for hydrogen in the NH₂ group of the N-terminal serine, NH₂ for OH” in the carboxyl of glutamine in position 5, and formyl for an amino hydrogen of lysine in positions 11, 15, 16, and 21 decreases or eliminates the ACTH-like activity of a synthetic tricosapeptide which duplicates the first 23 amino acids of naturally occurring ACTH.