Abstract
Discussion and conclusions
The increase in plasma corticosterone resting levels seen in the first few days after injection of GTG may be due to one or several mechanisms: alteration of the conjugation capacity of the liver(18) due to the drug itself or accompanying the diminished food intake that immediately follows GTG injection(6), thus leading to increased plasma concentrations of free Cpd. B; or actual stimulation of the hypothalamic centers related to ACTH release by development of the hypothalamic lesion.
These results show, at any rate, that the hypothalamic lesion produced in CBA mice by the dose of GTG used in this study does not inhibit release of ACTH normally produced by exposure to stress. Animals with this type of hypothalamic lesion, therefore. cannot be used for an assay of CRF.
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