Abstract
Summary
Auto-inhibition of DA virus plaque formation was observed in tissue cultures during serial passages of this virus. An inhibitor (interferon-like) substance was found in the virus-free culture fluids. The presence of such an inhibitor substance seemed to be the determining factor for the 2 unusual phenomena observed with the DA virus: 1) plaque formation under agar overlay without CPE in parallel fluid cultures, and 2) “prozone“ reaction in plaque formation.
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