Abstract
Summary
High concentrations of chick-adapted Sendai virus induced non-transmissible cytopathic effects in cultures of primary human amnion (HA) cells. Evidence was presented suggesting that an incomplete cycle of Sendai virus multiplication occurred. An interferon-like substance was liberated as early as 12 hours after inoculation of this virus. Titers of interferon ranged between 1:256 and 1:1024 as assayed in HA cells challenged with Sindbis or poliovirus. This and other interferons were far less effective in protecting HA cells against the non-transmissible cytopathic effect of Sendai virus. In contrast, however, these cells when previously infected with mumps, SV5, and DA viruses proved completely resistant to challenge with high concentrations of Sendai virus.
Get full access to this article
View all access options for this article.