Abstract
Summary
Nodules from adult C3H/Crgl females produce a high incidence of mammary tumors following transplantation into young females. On the other hand, nodules from two C3H sublines which lack demonstrable biologically active mammary tumor virus (MTV) rarely develop mammary tumors when similarly transplanted. Simple exposure to MTV (achieved by transplanting nodular outgrowth from the MTV-free sublines into MTV-infected C3H/Crgl hosts) does not create tumor potentials in these outgrowths equivalent to those seen in the C3H/Crgl population of nodules. It is concluded that a different population of nodules (with regard to tumor potential) is formed in the absence of the MTV than in its presence.
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