Plasma Cholesterol Concentrations in Cockerels and Dogs Treated with Bile Acid Binding Polymer and Cholesterol Synthesis Inhibitors

Abstract

Summary

In normocholesterolemic cockerels the bile acid binding polymer, cholestyramine resin (MK-135), lowered plasma cholesterol concentrations when fed in the diet; the hepatic cholesterol synthesis inhibitor, benzmalecene, lowered cholesterol levels when given by injection, but not when fed in the diet. In combination, their effect was additive. In dogs, feeding of cholestyramine resin plus benzmalecene or triparanol (MER-29) had additive cholesterol-lowering effect.