Abstract
Summary
Fresh human blood collected in heparin and glucose was incubated without and with tolbutamide for up to 48 hours. ATP levels in the tolbutamide samples were less than in the control samples although glucose utilization appeared to be the same. It was concluded that the changes in the blood nucleotide pattern were more subtle indicators of effects of tolbutamide on energy metabolism than more conventional measures such as glucose utilization, but the implications of the findings are not entirely clear.
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