Species Dependence of Chlorpromazine Metabolism. ∗

Abstract

Summary

Man and dog are compared with reference to their metabolism of chlorpromazine following its oral administration (8 mg/kg). Both qualitative and quantitative differences are noted in the urinary metabolite patterns. Humans tend to favor the excretion of polar derivatives, along with one or 2 major nonpolar metabolites (Nor₂CPSO, 3.7% and Nor₁CPSO, 1.8%). Their output of CP (0.2%) and CPSO (0.4%) is trivial. Dogs excrete less polar material, less Nor₂CPSO (1.1%), more Nor₁CPSO (5.1%) and substantial amounts of CP (2.8%) and CPSO (5.1%). The human polar fractions contain persulfate-blue as well as persulfate-lavender staining metabolites; the blue series is conspicuously absent from dog urine.