Establishment of Resistance to Gardner Lymphosarcoma (6C 3HED) and L#2 Lymphoma in G3H and A/He Mice. ∗

Abstract

Summary

It has been possible to produce complete protection in C3H mice to Gardner lymphosarcoma and to L#2 lymphoma, and in A/He mice to Gardner lymphosarcoma. Partial immunity was produced in A/He mice to L#2 lymphoma. This was accomplished by semiweekly intraperitoneal injections of 8 doses of 2000 r X-irradiated tumor. C3H mice immunized with Gardner and cross challenged with L#2 tumor and C3H mice immunized with L#2 tumor and challenged with Gardner tumor showed no significant amount of protection. However, A/He mice immunized with Gardner and challenged with L#2 tumor were partially protected. Plausible mechanisms of immunity production are discussed.