Abstract
Summary
Synthetic polyORN, polymyxin B, and protamine activate horse prothrombin by processes resembling the nonenzymic activation with polyLYS. Neomycin and streptomycin may function to a slight degree in the same mechanism. Nonenzymic prothrombin activation with polyLYS is inhibited by heparin, polyGLU, and polyASP. The capacity of protamine preparations to activate prothrombin is stable to heat, DFP, and dialysis. Prothrombin consumption in prothrombin-protamine-DFP mixtures is concomitant with thrombin formation in DFP-free systems. Nonenzymic prothrombin activation may be associated with some drug toxicities as well as with physiologic hemostasis.
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