Abstract
Summary
Cortisone acetate depressed adrenal weight and reduced adrenal cholesterol concentration in male and female rats. Methylandrostenediol (MAD) depleted adrenal cholesterol in both sexes while not influencing adrenal weight. When cortisone acetate and MAD were injected concomitantly, normal adrenal weights were observed in male and female rats. However, adrenal cholesterol content was protected by MAD only in cortisone-treated males. MAD did not prevent adrenal weight loss due to thiouracil, but did deplete cholesterol by 67%.
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