Abstract
Summary
Compounds in a steroidogenetic pathway (pregnenolone → progesterone (P) → 17α-hydroxyprogesterone → androstenedione → testosterone propionate) were tested to determine their mammogenic effectiveness (as determined by desoxyribosenucleic (DNA) measurement) in ovariectomized rat when injected with estradiol benzoate (EB). Results indicated that EB plus P produced greatest total mammary gland DNA. EB plus pregnenolone, 17α-hydroxyprogesterone, androstenedione or testosterone propionate produced 29.0%, 26.5%, 35.8%, and 33.0% of DNA produced by EB plus P over that produced by injection of EB alone.
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