Abstract
Summary
Sections of epiphyseal cartilage from rachitic rats, exposed to solutions of chlorpromazine in water, indicated binding of chlorpromazine to the cartilage surface. In contrast with control, the chlorpromazine pretreated cartilage showed little or no calcification after incubation for 20 hours in a calcifying solution, did not stain metachromatically with a toluidine blue O-calciumchloride solution, and did not bind luteocobalti chloride. Binding of chlorpromazine and/or calcium appeared to be of a competitive nature, excess of one reversing or preventing fixation of the other. Parallel chemical studies support the assumption that chlorpromazine interacts with the chondroitin sulfate of ossifying cartilage.
The authors are grateful to Dr. Bruno W. Volk for aid and encouragement.
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