Abstract
Summary
1. Pantothenic acid deficiency results in decreases in coenzyme Q and succinoxidase activity of liver. Administration of pantothenic acid to the deficient animals results in a restoration to normal by the end of 24 hours. 2. The deficient animals show decreased incorporation of labeled acetate and mevalonate into liver coenzyme Q, indicating a decreased synthesis of the coenzyme Q as the possible cause of lowered liver levels of coenzyme Q in pantothenic acid deficiency.
Grateful acknowledgement is made to Dr. O. Wiss, Hoffmann la Roche Ltd., Basle, Switzerland for the kind gift of mevalonic acid-2-C14 used in these studies. Our thanks are also due to the Indian Council of Medical Research for financial support and to Dr. V. Subrahmanyan, Director of this Institute, for his interest and encouragement.
Get full access to this article
View all access options for this article.