Abstract
Summary
A screening test is described for materials which suppress the immune response during its inductive phase. This test is based on the formation of hemagglutinins to sheep red blood cells in mice. 6-Mercap-topurine, 6-thioguanine and their S-imidazolyl derivatives, B.W. 57-322 and B.W. 57-323, show high activity.
The authors wish to acknowledge their indebtedness to Dr. Robert Schwartz for the suggestion which stimulated this investigation, and to thank Dr. R. Y. Calne and Dr. A. W. Frisch for the opportunities to read their papers in advance of publication.
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