Abstract
Summary
Mouse liver slices converted Tremorine to an active form which differed from non-incubated Tremorine preparations (a) by its faster onset of action in untreated mice and cats, (b) by not being blocked by SKF-525A (diethylaminodiphenylpropylacetate), an inhibitor of liver microsomal activity, (c) by stimulating rabbit gut in vitro and (d) by producing an immediate slowing of the heart and fall in blood pressure on intravenous injection into anesthetized dogs. Material having the biological properties of activated Tremorine was also found in the urine of rats and mice given Tremorine and in solutions of Tremorine incubated with hamster liver slices and with hamster and rat liver homogenates.
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