Abstract
Summary
In rats previously sensitized by a single oral dose of dihydrotachysterol (DHT), massive and rather selective calcification of the pancreas is induced by subsequent intraperitoneal administration of egg white. Intravenous injection of egg yolk elicits a calcinosis primarily affecting the reticuloendothelial cells of the liver and the spleen. Yet, other types of calcinosis are induced by intravenous injection of egg white or the intraperitoneal administration of egg yolk. It is assumed that albumen and yolk act as “vital mordants,” preparing the tissues of suitably sensitized animals for the subsequent uptake of calcium, distribution of the lesions being dependent upon the special distribution patterns of the mordants themselves.
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