Oxidative Effects of 1,1,3-Tricyano-2-Amino-1-Propene

Abstract

Summary

Administration of 1,1,3-tricyano-2-amino-1-propene (U-9189) increased total CO₂ output and oxidation of C₁₄-labeled acetate, tripalmitin, DL-leucine, and glycine in intact fasting rats. U-9189 also increased C₁₄ specific activity of exhaled CO₂ suggesting increased utilization in excess of increased metabolic rate. Total oxidation of C₁₄-glucose was not influenced; resultant specific activity was therefore decreased. Although in thyroidectomized rats U-9189 produced a similar increase in total CO₂ expired and oxidation of C¹⁴-DL-leucine, specific activity of total CO₂ increased only slightly compared to intact rats given U-9189. Total “oxidative effect” of U-9189 appeared to be lacking in the absence of thyroid gland.

The authors are indebted to Dr. Floyd S. Eberts, Jr. for a sample of U-9189.