Abstract
Summary
Metabolism of acetohexamide 1 - (p-acetylbenzenesulfl) -β -cyclohexylurea was investigated in dogs, rabbits, rats, and man. Trace amounts of unchanged drug were excreted by dogs and man. All species excreted the reduced form 1-(p-α-hydroxyethylbenzenesulfonyl) −3 -cyclohexylurea. In a dog, a rabbit and 2 human subjects, 49 to 59% was recovered as metabolite in the urine, but only 18% in the pooled urine of 6 rats. Chromatograms of rat urine revealed no other metabolites.
The authors are indebted to Messrs. D. O. Woolf and L. H. Howard for infrared and ultraviolet absorption data, and to Miss Ann VanCamp for x-ray diffraction patterns.
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