Abstract
Summary
Hydrocortisone inhibited the growth of cells in a synthetic medium. Degree of inhibition was proportional to concentration of the hormone and duration of exposure. The inhibition in nuclear multiplication was relatively greater than the inhibition of protein synthesis. The cells grown in media with hydrocortisone had larger, more variable nuclei, increased amounts of acid phosphatase and nonspecific esterase and decreased amounts of succinic dehydrogenase and glucose-6-phosphate dehydrogenase.
The authors gratefully acknowledge the technical assistance of Miss Virginia Jentoft and Miss Barbara Jennings.
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