Abstract
Summary
Immunological tolerance of AZ F1 hybrid tissue homograft induced in adult Z mice by virtue of parabiosis of 150 days duration can be transferred to isologous Z strain mice by injecting these animals at birth with spleen cells taken from Z donors tolerant of AZ F1 tissue. Tolerance resulting from parabiosis of only 30 days duration failed to be transferred by the same procedure.
In the light of these results the mechanism of tolerance induced in adult individuals by the parabiosis procedure is discussed.
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