Abstract
Summary
Ultraviolet inactivated herpes simplex virus prepared in rabbit kidney cell cultures was injected intravenously and in-traperitoneally into mice. The majority of mice so immunized survived a 1000 LD50 intracerebral herpes simplex virus challenge and were shown to possess neutralizing antibody against the virus. These findings are contrary to the findings of studies in which inactivated allantoic fluid virus was used as antigen. However, they are in agreement with early experiments which employed inactivated herpes simplex virus prepared in mouse or rabbit brain and a recent report in which antigen was also prepared in rabbit kidney cell culture.
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