Abstract
Summary
Synthetic lysine vasopressin was assayed for ACTH releasing activity in nembutal-morphine treated rats using fluorometric determination of plasma corticosteroids as index of ACTH release. A linear logdose vs response relationship was established between pressor doses of 8 to 67 mU. This activity was shown to be “CRF-like” rather than “ACTH-like” by its absence in hypo-physectomized rats injected with 67 mU of pressor activity.
The authors wish to express appreciation to Dr. Stephen Mandel, Dept. of Statistics, I.S.U., for many helpful discussions during this work.
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