Interrupted Enterohepatic Circulation of Bile and Its Effect on Urinary and Biliary Excretion of I 131 . ∗

Abstract

Summary

Total biliary diversion markedly depressed urinary excretion of I¹³¹ intravenously administered. The effect was apparent within 2 hr post choledochostomy. Fasting reduced urinary excretion of I¹³¹ to a minor extent; operative trauma had no effect. Treatment of bile fistula rats with donor bile and/or iodinated drinking water significantly increased I¹³¹ excretion. I¹³¹ content of bile was significantly reduced in bile fistula rats only through combined treatment with donor rat bile and iodinated drinking water. I¹³¹ content in urine paralleled that of sodium under some conditions but not in others.

The author is grateful to Roy Marrero for expert technical assistance in this study.