Abstract
Summary
Pangamic acid (Vit. B-15) possesses definite pharmacologic properties. These include neuromuscular blocking activity in the rabbit and chicken as well as production of hypotension in anesthetized dogs. Neostigmine methylsulfate is an effective antagonist to the neuromuscular blockade produced in the rabbit. These effects appear to be qualitatively similar to those reported for thiamine hydrochloride.
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