Abstract
Summary
The chromosomal anomaly of mongolism suggests the likelihood of enzymatic anomalies. In a series of enzymatic studies in mongolism a tendency to high oxygen uptake and low phosphorylation rate in the red blood cells was encountered. In the present study a high triiodothyronine uptake of rbc was found, which throws light on both the high respiratory rate and the uncoupling of phosphorylation. The range of high thyroid hormone uptake values was almost completely outside the range of normal controls, though a few adult psychiatric cases were found with slightly elevated values.
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