Immediate Decrease in Respiratory C 14 O 2 Excretion Following Simultaneous Intravenous Administration of NaHC 14 O 3 and Acetazoleamide in the Rat

Abstract

Summary

The effect of acetazoleamide on rate of expiration of carbon dioxide was studied in rats using carbon-14 labeled bicarbonate. A marked transient reduction in expired C¹⁴O₂ was observed during the first 10 minutes after simultaneous intravenous injection of the drug (70 mg/kg) and NaHC¹⁴O₃. The rate of appearance of C¹⁴O₂ was reduced 35 ± 7% in the treated animals 5 minutes after injection. When the animals were pretreated (30 minutes) with acetazoleamide (20 mg/kg) and when the labeled NaHC¹⁴O₃ entered the blood slowly as a result of intraperitoneal injection, the reduction in rate of C¹⁴O₂ elimination was not nearly as marked.