Abstract
Summary
The effect of acetazoleamide on rate of expiration of carbon dioxide was studied in rats using carbon-14 labeled bicarbonate. A marked transient reduction in expired C14O2 was observed during the first 10 minutes after simultaneous intravenous injection of the drug (70 mg/kg) and NaHC14O3. The rate of appearance of C14O2 was reduced 35 ± 7% in the treated animals 5 minutes after injection. When the animals were pretreated (30 minutes) with acetazoleamide (20 mg/kg) and when the labeled NaHC14O3 entered the blood slowly as a result of intraperitoneal injection, the reduction in rate of C14O2 elimination was not nearly as marked.
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