Abstract
Summary
Direct humoral control of parathyroid function has been demonstrated in dogs in which the isolated thyroid-parathyroid glands were perfused with high calcium or low calcium blood. The latter appears to release parathyroid hormone or a substance with identical action. The resulting rise in systemic blood calcium does not depend on a fall in the inorganic phosphate of blood. These experiments indicate a “feedback” mechanism involving the parathyroids which is sufficiently sensitive and fast-acting to account for the acute homeostatic control of blood calcium.
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