Abstract
Conclusions
1. A quantitative method based on the reaction of toluidine blue with heparin and “heparinoids” is described. It reveals a range of 9-24% output in the urine of injected heparin in normal individuals following a standard test dose of 25 mg of heparin. 2. The presence of dye-binding substances in varying amounts in the urine of infants, children, men, women, and during pregnancy, without an injection of heparin suggests the existence of a “heparinoid” metabolism.
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